Alexander Dilthey, PhD

Guest Researcher

Alexander.Dilthey

med.uni-duesseldorf.de

Alexander studied Computer Science in Germany and Switzerland and has a DPhil in Statistical Genetics from the University of Oxford (2012). He co-founded two companies, Peptide Groove LLP and Lighthouse Cancer Diagnostics Ltd. Since 2016 he is back in academia, first as a visiting fellow at NIH/NHGRI and now leading his own research group at the Institute of Medical Microbiology at the University Hospital of Dusseldorf. His research interests include assembly of the human genome's most complex regions (rDNA, KIR, HLA), immunogenetics and the development of "digital" approaches to detecting and treating disease. He maintains a guest researcher position with the Genome Informatics Section.

Projects

MetaMaps

Long-read metagenomic analysis

HLA*PRG:LA

Fast and efficient HLA typing from whole-genome sequencing data

MashMap

A fast and approximate long read mapper

News posts

Fast and highly accurate HLA typing by linearly-seeded graph alignment

March 22, 2017

Publications

see all 23 publications with Alexander Dilthey

HLA*PRG:LA - HLA typing from linearly projected graph alignments

bioRxiv, October 26, 2018

Full text

Dilthey AT, Mentzer AJ, Carapito R, Cutland C, Cereb N, Madhi SA, Rhie A, Koren S, Bahram S, McVean G, Phillippy AM

De novo assembly of haplotype-resolved genomes with trio binning

Nature Biotechnology, October 22, 2018

Koren S, Rhie A, Walenz BP, Dilthey AT, Bickhart DM, Kingan SB, Hiendleder S, Williams JL, Smith TPL, Phillippy AM

A fast adaptive algorithm for computing whole-genome homology maps

Bioinformatics, September 1, 2018

Jain C, Koren S, Dilthey A, Phillippy AM, Aluru S

Variation in human chromosome 21 ribosomal RNA genes characterized by TAR cloning and long-read sequencing

Nucleic Acids Res, July 27, 2018

Kim JH, Dilthey AT, Nagaraja R, Lee HS, Koren S, Dudekula D, Wood III WH, Piao Y, Ogurtsov AY, Utani K, Noskov V, Shabalina SA, Schlessinger D, Phillippy AM, Larionov V