Alexander Dilthey, PhD

Visiting Fellow

alexander.diltheynih.gov

Alexander studied Computer Science in Germany and Switzerland and has a DPhil in Statistical Genetics from the University of Oxford (2012). He co-founded two companies, Peptide Groove LLP and Lighthouse Cancer Diagnostics Ltd. Since 2016, he is back in academia, as a Visiting Research Fellow at NHGRI-NIH. His research interests include assembly of the human genome's most complex regions (rDNA, KIR, HLA), immunogenetics and the development of "digital" approaches to detecting and treating disease.

Projects

HLA*PRG:LA

Fast and efficient HLA typing from whole-genome sequencing data

MashMap

A fast and approximate long read mapper
News posts

Fast and highly accurate HLA typing by linearly-seeded graph alignment

March 22, 2017
Publications
High-Accuracy HLA Type Inference from Whole-Genome Sequencing Data Using Population Reference Graphs
PloS Comput Biol, October 28, 2016
Dilthey A, Gourraud PA, Mentzer AJ, Cereb N, Iqbal Z, McVean G
Comprehensive genome-wide evaluation of lapatinib-induced liver injury yields a single genetic signal centered on known risk allele HLA-DRB1*07:01
Pharmacogenomics J., April 16, 2016
Parham LR, Briley LP, Li L, Shen J, Newcombe PJ, King KS, Slater AJ, Dilthey A, Iqbal Z, McVean G, Cox CJ, Nelson MR, Spraggs CF