Arang Rhie, PhD

Staff Scientist

arang.rhienih.gov

Arang received a BS in computer science in 2009 and MS in bioinformatics in 2011 from Ewha Womans University. She completed her PhD in 2017 at the Genome Medicine Institute, Department of Biomedical Science, Seoul National University College of Medicine. Her dissertation research aimed to build the first high-quality Korean reference genome for use in medical diagnostics. After her post-doctoral training in the Genome Informatics Section at NIH/NHGRI, she is continuing her research as a staff scientist, focusing on the reconstruction and evaluation of true haplotypes from long-read sequencing and other emerging technologies. She is an active member of the Vertebrate Genomes Project (VGP), Earth Biogenome Project (EBP), Human Pangenome Reference Consortium (HPRC) and the Telomere-to-Telomere consortium (T2T).

Software

Merqury

Evaluate genome assemblies with k-mers and more

Winnowmap

A long-read mapping algorithm optimized for mapping ONT and PacBio reads to repetitive reference sequences.

SALSA

A tool to scaffold long read assemblies with Hi-C data

Canu

A single molecule sequence assembler for genomes large and small
Publications
A chromosome-level reference genome and pangenome for barn swallow population genomics
Cell Reports, January 31, 2023
Secomandi S … Rhie A … Formenti G
Recombination between heterologous human acrocentric chromosomes
bioRxiv, January 18, 2023
Guarracino A, Buonaiuto S, de Lima LG, Potapova T, Rhie A, Koren S, Rubinstein B, Fischer C, Gerton JL, Phillippy AM, Colonna V, Garrison E
Scalable Nanopore sequencing of human genomes provides a comprehensive view of haplotype-resolved variation and methylation
bioRxiv, January 15, 2023
Kolmogorov M … Rhie APhillippy AM … Paten B