Adam Phillippy, PhD
Senior Investigator
adam.phillippynih.gov
Adam is the director of the Center for Genomics and Data Science research and head of the Genome Informatics Section at the National Human Genome Research Institute (NHGRI). His lab develops efficient computational methods for analyzing DNA sequencing data, including tools for genome assembly, alignment, clustering, forensics, and metagenomics. He is a co-founder of the Telomere-to-Telomere Consortium and Vertebrate Genomes Project, which seek to enable the complete and gapless assembly of human and all other vertebrate genomes. He received a B.S. in computer science from Loyola University Maryland in 2002, where he was advised by Dr. Arthur Delcher. He first worked as a bioinformatics engineer at The Institute for Genomic Research (TIGR) with Dr. Mihai Pop, and later received a Ph.D. in computer science from the University of Maryland in 2010 with Dr. Steven Salzberg. After graduate school he led a bioinformatics group at the National Bioforensics Analysis Center before joining NHGRI in 2015. In 2019, he was awarded tenure by the NIH and received the U.S. Presidential Early Career Award for Scientists and Engineers. He was named by TIME magazine as one of the world’s most influential people of 2022 for his work on completing the human genome.
ModDotPlot
ModDotPlot is a dotplot visualization tool, built to quickly visualize large complex repeats within whole chromosomes.
Verkko
Verkko is a hybrid genome assembly pipeline developed for telomere-to-telomere assembly of long accurate (e.g. PacBio HiFi) and ultra-long (e.g. Oxford Nanopore UL) reads. Verkko is Finnish for net, mesh and graph.
Merqury
Evaluate genome assemblies with k-mers and more
Winnowmap
A long-read mapping algorithm optimized for mapping ONT and PacBio reads to repetitive reference sequences.
August 13, 2024
November 27, 2023
October 31, 2023
August 23, 2023
The formation and propagation of human Robertsonian chromosomes
bioRxiv, September 26, 2024
de Lima LG, Guarracino A, Koren S, Potapova TA, McKinney SA, Rhie A, Solar SJ, Seidel C, Fagen B, Walenz BP, Bouffard GG, Brooks SY, Peterson M, Hall KE, Crawford J, Young AC, Pickett BD, Garrison E, Phillippy AM, Gerton JL
Complex genetic variation in nearly complete human genomes
bioRxiv, September 25, 2024
Epigenetic control and inheritance of rDNA arrays
bioRxiv, September 16, 2024
Potapova TA, Kostos P, McKinney SA, Borchers M, Haug JS, Guarracino A, Solar S, Gogol MM, Anez GM, de Lima LG, Wang Y, Hall KE, Hoffman S, Garrison E, Phillippy AM, Gerton JL
ModDotPlot - rapid and interactive visualization of tandem repeats
Bioinformatics, August 7, 2024