Adam Phillippy, PhD

Investigator

adam.phillippynih.gov

Adam began his career at The Institute for Genomic Research in 2001, followed by graduate studies at the University of Maryland starting in 2005. After receiving his PhD in 2010, he started a research group at the National Bioforensic Analysis Center, and later moved to the National Human Genome Research Institute in 2015 to form the Genome Informatics Section. He has made foundational contributions to bioinformatics, specifically in the areas of genome alignment, genome assembly, and microbial forensics. Most recently, he has pioneered the use of single-molecule and nanopore sequencing for the accurate reconstruction of complete genomes at low cost.

Projects

MashMap

A fast and approximate long read mapper

Canu

A single molecule sequence assembler for genomes large and small

Mash

Fast genome and metagenome distance estimation using MinHash

MHAP

A probabilistic sequence overlap algorithm
News posts

MashMap: approximate long-read mapping using minimizers and MinHash

May 22, 2017

Assembling the Cliveome

April 28, 2017

Single-molecule sequencing and chromatin conformation capture enable de novo reference assembly

March 6, 2017

Assembly of a human genome from nanopore sequencing data

January 8, 2017
Publications
Draft Genome Sequences from a Novel Clade of Bacillus cereus Sensu Lato Strains, Isolated from the International Space Station
Genome Announcements, July 12, 2017
Venkateswaran K, Sielaff AC, Ratnayake S, Pope RK, Blank TE, Stepanov VG, Fox GE, van Tongeren SP, Torres C, Allen J, Jaing C, Pierson D, Perry J, Koren S, Phillippy AM, Klubnik J, Treangen TJ, Rosovitz MJ, Bergman NH
Analysis of the Aedes albopictus C6/36 genome provides insight into cell line adaptations to in vitro viral propagation
bioRxiv, July 1, 2017
Miller JR, Koren S, Dilley KA, Puri V, Brown DM, Harkins DM, Thibaud-Nissen F, Rosen BD, Chen X, Tu Z, Sharakhov IV, Sharakhova MV, Sebra R, Stockwell TB, Bergman NH, Sutton GG, Phillippy AM, Piermarini PM, Shabman RS
Evaluation of GRCh38 and de novo haploid genome assemblies demonstrates the enduring quality of the reference assembly
Genome Research, May 1, 2017
Schneider VA … Koren SPhillippy AM … Church DM