Adam Phillippy, PhD
Senior Investigator
adam.phillippy
nih.gov
Adam is the director of the Center for Genomics and Data Science research and head of the Genome Informatics Section at the National Human Genome Research Institute (NHGRI). His lab develops efficient methods for analyzing DNA sequencing data, including tools for genome assembly, comparative genomics, clustering, forensics, and metagenomics. He is a co-founder of the Telomere-to-Telomere (T2T) Consortium, the Human Pangenome Reference Consortium, and the Vertebrate Genomes Project, which, together, seek to enable the complete and gapless assembly of human and vertebrate genomes. He is a recipient of the U.S. Presidential Early Career Award for Scientists and Engineers, the NIH Director’s Award, the Ilchun Molecular Medicine Award from the Korean Society for Biochemistry and Molecular Biology, and a distinguished alumni award from Loyola University Maryland. He was named by TIME magazine as one of the world’s most influential people of 2022 for his work on completing the human genome, and is currently working to understand the function, evolution, and clinical relevance of the approximately 10% of the human genome newly uncovered by the T2T project.
ModDotPlot
ModDotPlot is a dotplot visualization tool, built to quickly visualize large complex repeats within whole chromosomes.
Verkko
Verkko is a hybrid genome assembly pipeline developed for telomere-to-telomere assembly of long accurate (e.g. PacBio HiFi) and ultra-long (e.g. Oxford Nanopore UL) reads. Verkko is Finnish for net, mesh and graph.
Merqury
Evaluate genome assemblies with k-mers and more
Winnowmap
A long-read mapping algorithm optimized for mapping ONT and PacBio reads to repetitive reference sequences.
January 2, 2025
August 13, 2024
November 27, 2023
October 31, 2023
Chromosome-level echidna genome illuminates evolution of multiple sex chromosome system in monotremes
Gigascience, January 6, 2025
Zhou Y, Jin J, Li X, Gedman G, Pelan S, Rhie A, Jiang C, Fedrigo O, Howe K, Phillippy AM, Jarvis ED, Grutzner F, Zhou Q, Zhang G
Verkko2: Integrating proximity ligation data with long-read De Bruijn graphs for efficient telomere-to-telomere genome assembly, phasing, and scaffolding
bioRxiv, December 22, 2024
Long-read sequencing of hundreds of diverse brains provides insight into the impact of structural variation on gene expression and DNA methylation
Gapless assembly of complete human and plant chromosomes using only nanopore sequencing
Genome Research, November 6, 2024