Adam Phillippy, PhD

Senior Investigator

Adam is a Senior Investigator and Head of the Genome Informatics Section at the National Human Genome Research Institute (NHGRI). His lab develops efficient computational methods for analyzing DNA sequencing data, including tools for genome assembly, alignment, clustering, forensics, and metagenomics. He is a co-founder of the Telomere-to-Telomere Consortium and Vertebrate Genomes Project, which seek to enable the complete and gapless assembly of human and all other vertebrate genomes. He received a B.S. in computer science from Loyola University Maryland in 2002, where he was advised by Dr. Arthur Delcher. He first worked as a bioinformatics engineer at The Institute for Genomic Research (TIGR) with Dr. Mihai Pop, and later received a Ph.D. in computer science from the University of Maryland in 2010 with Dr. Steven Salzberg. After graduate school he led a bioinformatics group at the National Bioforensics Analysis Center before joining NHGRI in 2015. In 2019, he was awarded tenure by the NIH and received the U.S. Presidential Early Career Award for Scientists and Engineers.



Verkko is a hybrid genome assembly pipeline developed for telomere-to-telomere assembly of long accurate (e.g. PacBio HiFi) and ultra-long (e.g. Oxford Nanopore UL) reads. Verkko is Finnish for net, mesh and graph.


Evaluate genome assemblies with k-mers and more


A long-read mapping algorithm optimized for mapping ONT and PacBio reads to repetitive reference sequences.


Long-read metagenomic analysis
News posts

Going ape for T2T

November 27, 2023

The Q100 project

October 31, 2023

A complete Y chromosome

August 23, 2023

It's finally finished!

March 31, 2022
Improved sequence mapping using a complete reference genome and lift-over
Nature Methods, November 30, 2023
Chen N-C, Paulin LF, Sedlazeck FJ, Koren S, Phillippy AM, Langmead B
Low mutation rate in epaulette sharks is consistent with a slow rate of evolution in sharks
Nature Communications, October 19, 2023
Sendell-Price AT, Tulenko FJ, Pettersson M, Kang D, Montandon M, Winkler S, Kulb K, Naylor GP, Phillippy A, Fedrigo O, Mountcastle J, Balacco JR, Dutra A, Dale RE, Haase B, Jarvis ED, Myers G, Burgess SM, Currie PD, Andersson L, Schartl M
Scalable Nanopore sequencing of human genomes provides a comprehensive view of haplotype-resolved variation and methylation
Nature Methods, September 14, 2023
Kolmogorov M … Rhie APhillippy AM … Paten B