Adam Phillippy, PhD
Senior Investigator
adam.phillippy
nih.gov
Adam is the director of the Center for Genomics and Data Science research and head of the Genome Informatics Section at the National Human Genome Research Institute (NHGRI). His lab develops efficient methods for analyzing DNA sequencing data, including tools for genome assembly, comparative genomics, clustering, forensics, and metagenomics. He is a co-founder of the Telomere-to-Telomere (T2T) Consortium, the Human Pangenome Reference Consortium, and the Vertebrate Genomes Project, which, together, seek to enable the complete and gapless assembly of human and vertebrate genomes. He is a recipient of the U.S. Presidential Early Career Award for Scientists and Engineers, the NIH Director’s Award, the Ilchun Molecular Medicine Award from the Korean Society for Biochemistry and Molecular Biology, and a distinguished alumni award from Loyola University Maryland. He was named by TIME magazine as one of the world’s most influential people of 2022 for his work on completing the human genome, and is currently working to understand the function, evolution, and clinical relevance of the approximately 10% of the human genome newly uncovered by the T2T project.
ModDotPlot
ModDotPlot is a dotplot visualization tool, built to quickly visualize large complex repeats within whole chromosomes.
Verkko
Verkko is a hybrid genome assembly pipeline developed for telomere-to-telomere assembly of long accurate (e.g. PacBio HiFi) and ultra-long (e.g. Oxford Nanopore UL) reads. Verkko is Finnish for net, mesh and graph.
Merqury
Evaluate genome assemblies with k-mers and more
Winnowmap
A long-read mapping algorithm optimized for mapping ONT and PacBio reads to repetitive reference sequences.
September 24, 2025
September 22, 2025
May 12, 2025
April 9, 2025
The formation and propagation of human Robertsonian chromosomes
Nature, September 24, 2025
de Lima LG, Guarracino A, Koren S, Potapova T, McKinney S, Rhie A, Solar SJ, Seidel C, Fagen BL, Walenz BP, Bouffard GG, Brooks SY, Peterson M, Hall K, Crawford J, Young AC, Pickett BD, Garrison E, Phillippy AM, Gerton JL
A complete diploid human genome benchmark for personalized genomics
bioRxiv, September 21, 2025
Analysis of a novel human protein, ORF3, encoded by spacer rDNA
Journal of Molecular Evolution, September 19, 2025
Chen Y, Kim JH, Lee HS, Koren S, Larionov V, Phillippy AM, Schlessinger D, Nagaraja R
A complete and near-perfect rhesus macaque reference genome: lessons from subtelomeric repeats and sequencing bias
bioRxiv, August 4, 2025
Zhang S, Xu N, Lu Y, Nie Y, Li Z, de Gennaro L, Fu L, Zhang Z, Chen J, Ma K, Yang X, Zhang J, Schmitz MT, Antonacci F, Bakken TE, Ventura M, Phillippy AM, Sun Q, Mao Y