Adam Phillippy, PhD
Senior Investigator
adam.phillippynih.gov
Adam is the director of the Center for Genomics and Data Science research and head of the Genome Informatics Section at the National Human Genome Research Institute (NHGRI). His lab develops efficient computational methods for analyzing DNA sequencing data, including tools for genome assembly, alignment, clustering, forensics, and metagenomics. He is a co-founder of the Telomere-to-Telomere Consortium and Vertebrate Genomes Project, which seek to enable the complete and gapless assembly of human and all other vertebrate genomes. He received a B.S. in computer science from Loyola University Maryland in 2002, where he was advised by Dr. Arthur Delcher. He first worked as a bioinformatics engineer at The Institute for Genomic Research (TIGR) with Dr. Mihai Pop, and later received a Ph.D. in computer science from the University of Maryland in 2010 with Dr. Steven Salzberg. After graduate school he led a bioinformatics group at the National Bioforensics Analysis Center before joining NHGRI in 2015. In 2019, he was awarded tenure by the NIH and received the U.S. Presidential Early Career Award for Scientists and Engineers. He was named by TIME magazine as one of the world’s most influential people of 2022 for his work on completing the human genome.
ModDotPlot
ModDotPlot is a dotplot visualization tool, built to quickly visualize large complex repeats within whole chromosomes.
Verkko
Verkko is a hybrid genome assembly pipeline developed for telomere-to-telomere assembly of long accurate (e.g. PacBio HiFi) and ultra-long (e.g. Oxford Nanopore UL) reads. Verkko is Finnish for net, mesh and graph.
Merqury
Evaluate genome assemblies with k-mers and more
Winnowmap
A long-read mapping algorithm optimized for mapping ONT and PacBio reads to repetitive reference sequences.
January 2, 2025
August 13, 2024
November 27, 2023
October 31, 2023
Chromosome-level echidna genome illuminates evolution of multiple sex chromosome system in monotremes
Gigascience, January 6, 2025
Zhou Y, Jin J, Li X, Gedman G, Pelan S, Rhie A, Jiang C, Fedrigo O, Howe K, Phillippy AM, Jarvis ED, Grutzner F, Zhou Q, Zhang G
Verkko2: Integrating proximity ligation data with long-read De Bruijn graphs for efficient telomere-to-telomere genome assembly, phasing, and scaffolding
bioRxiv, December 22, 2024
Long-read sequencing of hundreds of diverse brains provides insight into the impact of structural variation on gene expression and DNA methylation
Gapless assembly of complete human and plant chromosomes using only nanopore sequencing
Genome Research, November 6, 2024