Adam Phillippy, PhD
Senior Investigator
adam.phillippy
nih.gov
Adam is the director of the Center for Genomics and Data Science research and head of the Genome Informatics Section at the National Human Genome Research Institute (NHGRI). His lab develops efficient methods for analyzing DNA sequencing data, including tools for genome assembly, comparative genomics, clustering, forensics, and metagenomics. He is a co-founder of the Telomere-to-Telomere (T2T) Consortium, the Human Pangenome Reference Consortium, and the Vertebrate Genomes Project, which, together, seek to enable the complete and gapless assembly of human and vertebrate genomes. He is a recipient of the U.S. Presidential Early Career Award for Scientists and Engineers, the NIH Director’s Award, the Ilchun Molecular Medicine Award from the Korean Society for Biochemistry and Molecular Biology, and a distinguished alumni award from Loyola University Maryland. He was named by TIME magazine as one of the world’s most influential people of 2022 for his work on completing the human genome, and is currently working to understand the function, evolution, and clinical relevance of the approximately 10% of the human genome newly uncovered by the T2T project.
ModDotPlot
ModDotPlot is a dotplot visualization tool, built to quickly visualize large complex repeats within whole chromosomes.
Verkko
Verkko is a hybrid genome assembly pipeline developed for telomere-to-telomere assembly of long accurate (e.g. PacBio HiFi) and ultra-long (e.g. Oxford Nanopore UL) reads. Verkko is Finnish for net, mesh and graph.
Merqury
Evaluate genome assemblies with k-mers and more
Winnowmap
A long-read mapping algorithm optimized for mapping ONT and PacBio reads to repetitive reference sequences.
October 13, 2025
September 24, 2025
September 22, 2025
May 12, 2025
Origin and evolution of acrocentric chromosomes in human and great apes
bioRxiv, December 23, 2025
Solar SJ, Hebbar P, Gomes de Lima L, Sweeten A, Rhie A, Potapova T, de Gennaro L, Guarracino A, Kim J, Pickett BD, Paten B, Wilson MA, Koren S, Garrison E, Eichler EE, Ventura M, Gerton JL, Phillippy AM
Human acrocentric chromosome short arm de novo mutation and recombination
bioRxiv, December 17, 2025
Lin J, Mastrorosa FK, Noyes MD, Yoo D, Rhie A, Porubsky D, Hoekzema K, Munson KM, Koundinya N, Watkins WS, Jorde LB, Quinlan AR, Neklason DW, Phillippy AM, Eichler EE
Complete de novo assembly and re-annotation of the zebrafish genome
bioRxiv, November 17, 2025
Okendo J, Koren S, Rhie A, Torrado-Tapias A, Pickett BD, Brooks SY, Bouffard GG, Crawford JK, Sison C, Joardar VS, Murphy TD, Tierney JAS, Haggerty L, Martin FJ, Wilson C, Amores A, Postlethwait JH, Murphy J, Sakai N, Varga ZM, Phillippy AM, Burgess SM
The complete genome of a songbird