De novo assembly of haplotype-resolved genomes with trio binning
Our latest paper with Tim Smith (USDA) is now out in Nature Biotechnology — “Complex allelic variation hampers the assembly of haplotype-resolved sequences from diploid genomes. We developed trio binning, an approach that simplifies haplotype assembly by resolving allelic variation before assembly … Trio binning uses short reads from two parental genomes to first partition long reads from an offspring into haplotype-specific sets. Each haplotype is then assembled independently, resulting in a complete diploid reconstruction.” Here are links to the full paper and a nice summary from NHGRI with quotes from me and Tim. Credit to Sergey Koren and Arang Rhie for developing this great new method. We have many more trios planned!